Sample Case Studies:

• Chapter 10: Case Study I
• Chapter 11: Case Study II

Sample Calculations:

• Part I: Post-Math Test
• Chapter 1: Summary Pratice Problems from Chapter 1, Clinical Calculations

Practice Modules and Lectures:

Module 1: Pharmacokinetics

• Clinical pharmacokeinetics
• Compartmental analysis of drug distribution
• Drug absorption and bioavailability
• Effects of renal disease on pharmacokinetics
• Pharmokinetics in patients requiring renel replacement therapy
• Effects of liver disease on pharmacokiinetics
• Noncompartmental vs. compartmental approaches to PK analysis
• Distributed models of drug kinetics
• Population pharmacokinetics

Module 2: Drug Metabolism and Transport

• Pathways of drug metabolism
• Chemical assay of drugs and drug metabolites
• Pharmacogenetics
• Drug interactions
• Biochemical mechanisms of drug toxicity
• Equilibrative and concentrative transport
• P-glycoprotein and drug transport

• Dose response and concentration response analysis
• Physiological and laboratory markers of drug effect
• Disease progression models and clinical trial simulation

• Drug therapy in pregnant and nursing women
• Development pharmacology
• Drug therapy in the elderly
• Clinical analysis of adverse drug
• Quality assessment of drug therapy

• Drug Discovery
• Pre-clinical drug development
• Animal scale up and Phase I studies
• Pharmacokinetics of biotechnology products and large molecules
• Design of clinical drug development progams
• Role of the FDA in guiding drug development

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